Discovery and Development of Innovative Derma-cosmetics and Biomedical Ingredients

Increasing number of savvy consumers has led to a grow in demand for high-performing dermacosmetics. Discover fundamental targets, such as the cutaneous nervous system, for the development of unique substances which can be patented and developed into new, innovative cosmetics and medical products. Computational design, sensory neurobiology, and functional validation are incorporated to accelerate development of efficacious molecules.

The technology is a combination of different R&D platforms :

- Molecular modelling platform using computational design methods to screen virtual chemical libraries, improve efficacy of peptides, synthetic and natural compounds as active ingredients,characterise physico-chemical and organoleptic properties of compounds, evaluate their toxicity and bioavailability, and design new molecules to disrupt protein-protein interactions.

- High-throughput screening platform for functional molecular, immunological, and cellular assays, including in primary sensory neuron culture, neuron-like cells, and human cells.

- Lead Molecule validation platform focuses on the functional study of receptors, ion channels, molecular targets, and protein-protein interactions. Useful to study the activity of a new compound on a specific receptor, and 3D skin model to test efficacy in a physiological model.

- Functional neuronal validation platform employs complex skin and simplified neuronal models to explore the efficacy of candidate compounds in various altered or physiological contexts. Techniques are specifically optimised to characterise the mode of action of each new molecule and/or receptor.

Develop new cosmetic active ingredients, active pharmaceutical ingredients (API), or new compounds with scientifically-proven activities to claim. 

• Discover and develop of ingredients starting with computational design of new ingredients according to desire effect.
• Characterise activity of new ingredients and validate claims
• Reposition existing ingredients by testing activity on new targets

Innovation in cosmetic and pharma ingredients, but also supplements, either by developing new ingredients either by repositioning existing ones.Computational design allows the optimization of new ingredients development by reducing the number of assays needed to find the desire compound, saving time and money for the project development.

Customers decide the type and extend of R&D according to needs, from computational design of the compounds and/or their targets, to their functional validation. The company also provides scientific advice for intellectual property generation.