Adhesions are fibrous bands that form between tissues and organs that are not normally connected. Up to 93% of patients develop adhesions following a laparotomy procedure.
Current solutions in the market include pharmacological treatment such as antibiotics to prevent infection; anticoagulants; and fibrinolytic agents, and physical solutions such as adhesion barriers. Adhesion barriers should achieve effective tissue separation, remain biologically active in the presence of blood and during the wound healing period, and can be absorbed without bringing about proinflammatory tissue response.
However, current solutions are not able to fully reduce or prevent adhesions and existing barrier films have reported adverse events.
This technology offer from a Singapore startup is for a proprietary anti-fibrinolytic and anti-inflammatory plant-derived biopolymer postoperative adhesion barrier as spray-on-gel or hydrogel film.
The biopolymer is derived from sunflower pollen which contains bioactive ingredients that prevent the cellular mechanism and signalling pathway of fibrogenesis. It also contains an abundance of phenolic acid that exhibit immunomodulatory and cellular antioxidant activities.
The sunflower pollen minimizes the chances of offsite migration and reduces the need for the barrier to be sutured in place.
The plant-derived biopolymer can be formulated into various forms to suit different wound types such as hydrogel film for open surgeries and spray-on-gel for keyhole and closed surgeries.
There are functioning prototypes that have went through in-vitro validation on anti-inflammatory and hemostasis, and adjacent animal studies. Results are encouraging in the initial animal studies.
The biopolymer technology can be applied to the following:
Categories of resulting products include:
Total Market Value in the Global Adhesion Barriers Market 2019 stands at $820 Million and Projected Total Market Value in the Global Adhesion Barriers Market 2024 is $1.310 Billion.
The technology includes bioactives which maximize the efficiency of the adhesion barrier and shows high efficacy in decreasing the incidence rates of formation of postoperative adhesions.