TECH OFFER

Non-invasive Cellular-resolution Medical Imaging using Optical Coherence Tomography

KEY INFORMATION

TECHNOLOGY READINESS LEVEL (TRL):
LOCATION:
Singapore
ID NUMBER:
TO174219

TECHNOLOGY OVERVIEW

Current cellular-level imaging tools are mostly invasive, which may be associated with serious complications. Micro-optical coherence tomography (µOCT) is capable of identifying cellular structures in mucosal tissues. One of the applications is rapid detection of precancerous lesions in surgical specimens, with an accuracy of 95% in the first clinical trial involving 58 patients. Other applications include noninvasive blood cell count and diagnosis of skin diseases.

TECHNOLOGY FEATURES & SPECIFICATIONS

µOCT comprises a broadband light source, an imaging console, and a handheld flexible imaging probe. Owing to the novel optical designs and signal processing algorithms, µOCT provides a spatial resolution of 1-2 µm, which is more than one order of magnitude higher than the standard OCT products. The imaging speed is up to a few hundred frames per second. The 3D imaging range is 2 mm by 2 mm by 1 mm (Width by Length by Height). The imaging range can be improved by relieving the resolution requirements.

POTENTIAL APPLICATIONS

1. Rapid detection of pre-cancerous lesions in surgical specimens;  - fast, sensitive, high resolution, specificity in detection of pre-cancerous cell vs benign cell.  2. Intraoperative positive margin detection;  - on-site, on-the-dot, detection of the margin between pre-cancerious cell vs benign cell.  3.   Non-invasive blood cell count - totally no adverse health impact and well-received by patients

Benefits

1.      Rapid detection of precancerous lesions in surgical specimens will help to make a timely diagnosis and save histology costs. 2.      Intraoperative positive margin detection will provide quick feedback on the positive margin during a surgical operation or endoscopic operation and avoid repeat surgery and associated complications; 3.      Noninvasive blood cell count will avoid invasive procedures and resultant complications, and improve patient’s life quality.