TECH OFFER

A Molecule for Ex-vivo Cord Blood and Cell Expansion

KEY INFORMATION

TECHNOLOGY CATEGORY:
Healthcare - Pharmaceuticals & Therapeutics
TECHNOLOGY READINESS LEVEL (TRL):
LOCATION:
Singapore
ID NUMBER:
TO174276

TECHNOLOGY OVERVIEW

A proprietary lead compound that expands hematopoietic and progenitor cells ex vivo has been shown to be able to generate sufficient amount of blood stem cells product for a clinically meaningful dose in adult transplant patient. Expanded grafts showed excellent functionality upon engraftment in immunodeficient mice.

TECHNOLOGY FEATURES & SPECIFICATIONS

Unique features of the lead compound as an expansion agent: 1) allows faster and lasting engraftment, 2) multi-lineage repopulation capacity of expanded graft in primary recipient mice, 3) freeze-thaw tolerant grafts with respect to in vivo repopulation capacity, 4) expanded cells that are free of karyotypic alterations and leukemic morphology, 5) the only known small molecule that expands cord blood without prior CD34+ enrichment.

POTENTIAL APPLICATIONS

Hematopoeitic stem and progenitor cell expansion for transplantation targeting acute leukemias, lymphoma and myelodysplasia as primary indications Off-the-shelf therapy to improve outcomes in intensive chemotherapy Expansion of grafts in cell banks Expansion for gene therapy application
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