Nowadays, the treatments of neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases are mainly for symptom relief, which is not a cure for patients. Regarding this problem, the restoration of degenerating neurons becomes imperative for the treatments. In recent years, medical researchers believe that the self-renewal ability of stem cells not only can potentially cure neurodegenerative diseases but also able to remedy impaired areas in the body. Stem cells are undifferentiated biological cells that can be differentiated into specialised cells in human body. Many scientists are devoted to developing methods of extracting stem cells from skin or blood, and therefore extraction of stem cells brings a controversial issue. This invention relates to a new method for extracting biological cells focusing on an innovative therapy for the subject diseases by means of personalised neural stem cells from patients themselves. With this novel technique, magnetic nanoparticles covered with antibodies can safely extract neural stem cells from rats. Neurospheres are successfully generated in vitro from the extracted neural stem cells and subsequently transplanted back to the same rat. Through this demonstration, it has been proved that the magnetic microsurgery process is simple and safe to be implemented on animals.
It is anticipated that the technology may have significant implications in isolating individual patients’ own neural stem cells for tailor-made treatments of their specific neurological problems in future stem cells therapy without the concern of ethical issues. The technology features could be summarised as follow: • Simple and safe to implement • Low risk of repellency
This invention can potentially cure neurodegenerative diseases and remedy impaired areas in the body. The technology can provide another mean to enhance the cell proliferation and differentiation without using the conventional methods which are potentially biohazard. From the technical perspective, a safer and more controllable treatment was established. The present invention can be licensed to hospitals around the globe for conducting the autologous call replacement therapy.
This invention may introduce the only way to cure neurodegenerative disease or to remedy impaired areas in the body.