Efficient production of bioactive cordycepin from Cordyceps militaris for pharmaceuticals, nutraceuticals or cosmeceuticals application

Technology Overview

Cordyceps species is a parasitic complex of fungus that is well known in Korea, China and some Asian countries for centuries due to its medicinal value. Cordycepin is the bioactive substance derived from the caterpillar fungus Cordyceps militaris and has recently become a promising raw material for both pharmaceuticals and cosmetics applications. Cordycepin has been demonstrated to have many pharmacological activities, such as anti-tumor, anti-metastatic, immunomodulatory and anti-inflammatory activities.

In recent years, many cosmetics and skin care products supplemented with natural products including mushroom/fungus has claimed much attention for their medical effects. The anti-oxidative and potent anti-aging activity of cordycepin have also been demonstrated by in vitro experiments. A growing demand on commercially feasible procedures for isolation and purification of cordycepin has fuelled a need for this invention.

The researchers have developed an efficient and commercial method to culture, produce and purify high purity cordycepin. A specific strain of C.militaris with high cordycepin production capacity was developed and cultured which facilitated a one-step crystallization process to extract cordycepin. A qualitative purity of 98% was achieved through using different parameters adopted from prior solubility tests into the crystallization process. The simplification of this invention serves as a major advantage compared to other methods. 

Technology Features & Specifications

In order to improve cordycepin production to a commercial level, a novel proprietary C. militaris strain has been developed under optimized condition. This included a thorough and specific optimization in the culture medium, maximizing production quantity and a detailed crystallization process to extract the cordycepin at the highest possible purity. This strain of fungus is capable of producing 2.8-fold higher concentration of cordycepin than the wild-type species with a high cordycepin yield of 14.3g/L and purity of 98% was successfully obtained.

Potential Applications

The C. militaris fungus contains the potent biometabolite called cordycepin which is sought after for its wide spectrum of benefits such as its anti-cancer, anti-oxidant and anti-inflammatory properties. The potential of this technology can be adopted by the following industry:

  • Cosmetics industry
  • Pharmaceuticals industry
  • Nutrition & Health supplement products
  • Traditional Chinese Medicine

Market Trends and Opportunities

The potential application of cordycepin in the cosmeceutical, nutraceutical and pharmaceutical industry is immense. The global pharmaceutical industry has been projected to increase by 6.3% CAGR from 2016 – 2022 with an overall market valued at USD1.12 trillion at the end (Evaluate Pharma). Likewise, the cosmeceutical industry is also forecasted to rise with a CAGR of 8.52% or USD 68.7 billion at the end, for the same period (Mordor Intelligence). 

Customer Benefits

This technology allows sustainable, economical and viable source of cordycepin production

The C. militaris fungus has many health benefits in terms of nutritional and medicinal value.

  • Antioxidant properties
  • Anti-aging effect on skin
  • Skin beauty and Care
  • Anti-inflammatory action
  • Anti-bacterial activity
  • Anti-asthma
  • Anti-diabetic
  • Immunoregulatory

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