Para-phenylenediamine (PPD) is a widely used chemical substance in hair dyes to give a natural look and prevent the loss of colour during shampooing and washing. Partially oxidised form of PPD, may cause contact allergic dermatitis in sensitive individuals and it was declared the Contact Allergen of the Year for 2006 by the American Contact Dermatitis Society (ACDS). Though manufacturers have begun para-toulenediamene sulfates (PTDS) as a substitute to PPD, research has shown that 43% of PPD-allergic patients also cannot tolerate PTDS. Therefore, there is a need for a new substitute for PPD.
The technology involves the structural modification of PPD. Among the PPD derivatives, a few promising candidates showed a reduced sensitizing potential in the Direct Peptide Reactivity Assay (DPRA, recognized by the OECD guidelines as a test to predict skin sensitization), stably coloured bleached hair samples without staining the skin and confirmed minimal penetration through the skin in ex vivo skin penetration studies.
To replace PPD in PPD-containing products such as:
The global dyestuff market is expected to grow at a compound annual growth rate of 8.8% to USD 306.2 million by 2025. There is currently no dye product that can claim to be hypoallergenic. In view of the growing market of beauty and personal care technologies, our technology provides huge commercial potential for consumer-friendly cosmetic products.