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Improved In-Vitro Fertilization through Enhanced Characterization of the Endometrium

Technology Overview

During in vitro fertilisation, embryo implantation represents one of the most important steps in the procedure. The blastocyst gets attached to the maternal endometrium. A successful implantation requires a receptive endometrium and functional embryo(s). The endometrium remains receptive for relatively short period of time, lasting a few days. This period is called an implantation window. The endometrium cannot receive the embryo either before, or after this period. The implantation window varies from person to person.

Currently with the help of biochemical signs (urine LH peak) the presence of the implantation window may be deduced. The LH peak makes the adequate status of the endometrium probable but it does not examine the endometrium itself, the ultimate answer for the condition of the endometrium can be given with the examination of the endometrium itself.

This innovative method examines the endometrium with the help of molecular biology, as opposed to the traditional approaches, to see whether its status corresponds to the prerequisites of implantation.

Technology Features & Specifications

This technology offers an innovative method to identify the receptive status of the endometrium, i.e. the implantation window. It employs both endometrium biopsy and minimally invasive approaches together with molecular characterization by gene expression methods.Expression of a particular set of genes which can characterise the status of the endometrium can be determined from a small tissue sample.This technology can be integrated with existing laboratories infrastructure.

Potential Applications

This technology can be used in In-Vitro Fertilisation procedures. 

Market Trends and Opportunities

The Global In-Vitro Fertilization (IVF) market is expected to garner $21.6 billion by 2020. The factors that contribute to the market growth are the emerging trend of starting families at a later age, increasing incidence of infertility and continuous efforts by the industry contributors. 

Customer Benefits

The technology is fully scalable as it uses instruments and skills that are available in major diagnostic laboratories all over the world.By analysing a set of biomarkers a receptive endometrium can be determined. This can increase the efficiency and success of IVF.

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