This technology is a non-toxic, biodegradable adhesive that allows bonding on wet surfaces, sealing of porous surfaces, and encapsulation of small molecules for controlled release devices. It is formulated with liquid polycaprolactone, a bioresorbable polymer, that has been exploited for production of polyurethane adhesives, medical devices, and drug delivery systems. The adhesive is hydrophobic, VOC-free, and is liquid at room temperature, and contains no toxic free radical initiators, hardeners, or other environmentally unfriendly ingredients. Upon activation by a simple hand-held UV LED, the liquid adhesive transitions into a cross-linked, expanding biorubber that non-specifically adheres to almost any surface. By exploiting carbene-crosslinking chemistry, it avoids the limitations associated with acrylates, epoxies, and urethane resins. This technology is currently being explored for tissue adhesives, medical coatings, controlled-release encapsulants, and cosmetics.
This technology has the following features: Liquid phase at ambient temperatures with apparent viscosities under 1 Pa.s (1,000 cP), requires no dilution in aqueous or organic solvents – in the pure form, it flows easily via syringe or other liquid applicators. Available in a range of viscosities and cured material properties – cured elasticity can be tuned precisely for application specific properties due to the flexibility of the synthetic methodology. The synthetic methodology allows a scalable yield production, from laboratory batch production to continuous reactor-scale production. Naturally hydrophobic material that prevents water infiltration into the polymer matrix – allows long-term shelf storage of 12 months or greater at ambient conditions. Can act as water impenetrable sealants and coatings on both dry and wet surfaces –can be modified to be both aqueous porous and non-porous with pore-forming additives. Unique formulations allow temporary reduction of adhesive fouling caused by surface water-hydration – the amount of surface water-hydration is reduced, after 10 seconds, upon contact with wet substrates. Subsequent UV-LED curing allows increased substrate bonding. The inclusion of polycaprolactone precursors allows linear and branched polycaprolactones to be dissolved – formulate unique composites, for pre- and post-cured adhesives, with tunable chemical and mechanical properties. Adhesive curing is activated through UV-A irradiation over a wide range of intensities – enables partial curing to control viscosity (sealants) and end-stage material properties. Allows bonding on nearly all substrates, including thermo-labile, flexible, or hydrated surfaces.
Medical Applications: Tissue adhesives Medical coatings Biosensor implants Topical skin therapies Drug depots Biologics encapsulation Dental restorations Minimally invasive surgeries Soft tissue sealants Plastic surgery fillers Biotechnology Applications: Green adhesives Non-fouling surfaces 3D cell culture Multi-purpose sealants Cosmetics Temporary tattoos/skin explants Controlled chemical release Fragrances Aquarium cements Expanding fillers Biosensors Veterinarian products
Widely customisable biopolymer that is rapidly tailored for unique and unmet applications.