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Microsphere-assisted Super-resolution Optical Microscope

Technology Overview

Microscale structure observation and characteristics study are crucial in the investigation and research in a variety of fields such as materials, biology specimen and particles. As 200nm has typically been the barrier for common optical microscope resolving power, the solutions to study sub-200nm structures have been mainly electron microscopes and confocal microscopes. However, both technologies usually require significant cost and are vulnerable to the short lifecycles of certain key components critical to the systems. Moreover, the complex or specially processed sample observation settings substantially limit the scope of applications of these solutions and techniques.

The developed technology not only achieves up to 137nm resolution, it also allows for a more affordable adoption of this microscopy technology by a diverse sector of users, ranging from laboratories use to being applicable in material, biochemistry and semi-conductor fields.

Technology Features & Specifications

The developed microscope utilises patented microsphere technology, increasing the resolution to sub-200nm.  

  • Resolution of up to 137nm resolving power
  • Autofocus and large Field of View (FOV) up to 3mm in diameter through image stitching
  • Natural ambient air observation in common room environment
  • Digital camera imaging and fast data acquisition
  • Plug-n-play installation

Potential Applications

  • Materials - Nanoscale materials study
  • Biology - Biomedical and biochemistry aspect of cells, bacteria, virus and particles
  • Semi-conductor - Silicon wafer process, wafer fabrication, circuit (wafer or chip) inspection

Market Trends and Opportunities

According to Grand View Research, the global market size of super-resolution microscopes is valued at USD 2.8 billion in 2018, projected to increase at a CAGR of 11.7% between 2019 to 2026. The market drivers are likely due to technology advancements, increasing focus on nanotechnology as well as the rise of application in the life science industry. Hence, there is a significant potential market opportunity for super-resolution microscopes.

Customer Benefits

  • More affordable and less complex to operate and maintain, as compared to existing alternative technologies
  • Minimal constraints in sample settings due to natural ambient air observation environment comparable to a common compound microscope
  • Capable of constructing real-color images of observation targets

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