Electrochemical and optical biosensors, which are dominant technologies in the global biosensor market, have the disadvantage of long assay time, labelling, sophisticated infrastructure and expensive reagents in point-of-care diagnostic assay. The micro/nanofabrication technologies and the discovery of abundant nanoscale materials have now opened up new possibilities for developing novel bioelectronic sensors, which are sensitive, robust, portable, and inexpensive and hold great potential for applications in a wide variety of areas, ranging from diagnosis of life-threatening diseases to point-of-care diagnosis.
The multi-sensing nanoscale biochips is a platform for assembling different molecular building-blocks between independent carbon nanoelectrodes in order to allow ultrahigh sensitivity with simultaneous detection of multiple biological targets on a single-biochip at low fabrication costs. It could also provide a biocompatible and ﬂexible platform for the low cost fabrication of miniaturized bio-sensing devices with applications in wearable and/or implantable products.
May provide a biocompatible and ﬂexible platform for the low cost fabrication of miniaturized bio-sensing devices
Given its compatibility with virtually any protein or aptamer biomolecule, this technology provides a platform biosensor capability with broad applicability. Markets of particular interest include point-of-care and home diagnosis and emerging smaller markets such as automotive. The platform is expected to be compatible with blood, saliva and sweat.
Given this technology can carry out single-molecule investigations, which in turn enables monitoring biomolecular interactions with high sensitivity/selectivity in real time, using small analyte volumes and concentrations, this technology is also of interest as a research tool in a variety of ﬁelds ranging from molecular electronics to fundamental biology.
Researchers have successfully demonstrated the low-cost assembly via dielectrophoresis of several aptamer-functionalised DNA-wrapped CNT junctions between electrode pairs and their use for multiplexed sensing.
This technology combines at low cost: