Bone graft and scaffolds trend to high demand according to increasing of world aging population. Self-setting synthetic bone substitutes related to the synthetic cement-type materials and scaffold materials, which can used to repair, restore and augment bone due to accident, trauma and broken bone from osteoporosis. The most commonly used bone graft materials include autologous bone (own bone), allograft (bone from another human) and xenograft (bone from another species). These materials have significant disadvantages that can be patient pain, risk of diseases transmission, lack of biocompatibility, cost effective and immunogenic responses. Therefore, the novel bone substitutes which can be used as alternatives for skeletal and orthopedic repair. The development of medical diagnosis such as CT-Scan, 3D MRI allow us to observe the complex defect bone. This technology will help surgery for treatment of the complicated broken bone cases. This innovation can be provided in a physical form that able to injected, flowed or applied to the site of action in a manner that will permit a minimum of invasive surgery and contacted the parts to be joined. It should be able to easily mold to a bony defect or 3D printing with a practical time to harden. Finally, the ideal bone substitute should be bioactive, biodegradable, osteoconduction, able to be sterilized, and readily available, at a reasonable cost to purchase and use. The calcium phosphate-based bone cement also be useful for self-setting without generating free-radicals or heat sufficient to harm surrounding tissues.
This technology is a new synthetic alternative for bone substitutes because - Easy to mix between cement powder and liquid to obtain the paste - Non-exothermic setting to avoid cell damage - Injectable, moldable to the complex shape without post-processing - Cost effective and high compliance since no further operations are need - Mechanical strength of 25-33 MPa and gradually degrade to create a porous bone graft ideal for bone tissue growth - Porosity of 60% with mesopore (2-50 nm) and macropore (more than 75 mm) for allowing the bone cell in-growth - High biocompatibility, high bioactivity and osteoconduction This innovation can set quickly, and to develop a sufficient mechanical strength upon setting and bioresorbable by the host
Self-setting synthetic bone ideal for natural human bone is synthesized from commercial chemical of calcium phosphate powder and biopolymer fibers. This material is purity and medical grade quality with cost effective. - To enhance its osteoconductive properties, this technology can be included with bone marrow aspirate, growth hormone or platelet rich plasma and stem cell - High potential development with 3D printing technology to fabricate the complex shape as custom-made bone. - High demand for world aging population in near future High potential for applying to big market of cosmetic surgery such as augmentation rhinoplasty and dental augmentation
Cost effective To improve quality of the patients, elderly’ lives Small surgery and fast-recovery No post-operate required No risk of diseases transmission