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In Vitro Diagnostic Equipment for Asthma and Respiratory Disease such as COPD (Chronic Obstructive Pulmonary Disease)

Technology Overview

Respiratory diseases such as COPD (chronic obstructive pulmonary disease) and asthma rapidly increase due to environmental changes and aging. COPD is the third leading cause of death (WHO 2012). Respiratory diseases have chronic disease characteristics and require early diagnosis and continuous management. Conventional spirometry devices are difficult to diagnose COPD and asthma. A new combined respiratory diagnostic system is needed for easy diagnosis of patients with respiratory diseases.

Conventional tests such as pulmonary function tests, asthma induction tests, and sputum tests can diagnose asthma. Pulmonary function test confirms how narrow the bronchus is, and it can be diagnosed by confirming whether the narrowed bronchus is wide enough by inhaling the bronchodilator. Asthma is diagnosed by proving the hypersensitivity of the airway by inhaling the bronchodilator. Sputum test, diagnoses asthma by directly observing allergic inflammatory cells in the sputum.

Current IVD Gas sensor has issues with accuracy and humidity. MOS (metal oxide semiconductor) sensor is widely used, but it has to solve sensitivity and high temperature operation problems. Accuracy of conductive polymeric sensor depends on humidity included in exhalation. Light sensor has good sensitivity, but has big size and higher price.

Technology Features & Specifications

First technology, "NO Gas Sensor" with lower limit of detection ~0.01ppm. The surface area is increased by defect (open hole) formed on SWCNT surface. SWCNT with defect was treated with amine functionalization to increase reaction and selectivity to NO gas. The inner wall of the SWCNT also contributes to the reaction of NO gas, thus enhancing the sensing characteristic.

Second technology, "CO Gas Sensor" with lower limit of detection ~1ppm. Function of the gold nanoparticle placed on the SWCNT surface to adsorb CO gas molecules in the air to gold nanoparticles. Charge transfer happens between the adsorbed CO Gas molecules and SWCNT. Conductivity changes when CO gas is detected.

Potential Applications

Respiratory diagnostic system for patients with respiratory diseases.

Market Trends and Opportunities

Revenue for sensors in Healthcare & Medical reached 14.1 Bio USD in 2016 and is expected to reach 29.5 Bio USD in 2022. This is driven by strong growth for wearable and home diagnostic equipment.

Customer Benefits

COPD is the third leading cause of death (WHO 2012), 50% increase over the last 10 years. Chronic Respiratory diseases require early diagnosis and continuous management. Sensor array based exhalation gas analyzer is needed to increase accuracy of disease diagnosis and facilitate disease classification.

This technology, combined respiratory diagnostic system is effective for easy diagnosis of patients with respiratory diseases.

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