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Superoxide dismutase (SOD) is a key antioxidant enzyme that protects cells from oxidative stress by catalysing the conversion of superoxide radicals into less harmful molecules like oxygen and hydrogen peroxide. These radicals are produced during normal cellular metabolism but can cause significant damage to DNA, proteins, and lipids if not neutralised. SOD helps maintain cellular integrity by reducing this damage, supporting overall health and longevity. Given its role in protecting cell damage, SOD has been utilised in skincare products, cosmeceuticals, dietary supplements, medical and therapeutic products as well as functional foods. Current methods to produce SOD include natural extraction from plants, microbial fermentation and recombinant DNA technology. However, challenges such as low yield, variation in quality and concentration, high costs and regulatory issues still remain. The technology owner uses specific strains of microorganism and advanced biotechnology processes to produce SOD at high yields via fermentation in a sustainable and efficient manner. The enzyme is then extracted and concentrated during downstream processing. This technology could ensure a consistent and scalable supply of SOD for commercial use. The company is seeking collaborations with skincare brands and cosmetic manufacturers interested in co-developing or licensing the technology for mass-market production and distribution. Sustainable and efficient manufacturing: Produced through microbial fermentation using specific and proprietary microorganisms to ensure high yield and purity. High enzyme activity: SOD activity is measured in units (U), typically ranging from 2,000 to 20,000 U/ml, depending on the downstream process, and intended application. pH stable: Active across a wide pH range, typically stable between pH 4.5 to 8.5, making it suitable for various formulations in supplements and cosmetics. Temperature stable: Optimal activity at temperatures between 20°C and 40°C. Some formulations may include stabilisers to maintain activity at higher temperatures. Water soluble: Allowing easy incorporation into aqueous formulations for cosmetics or supplements. Varied formats: Available in liquid concentrate or lyophilised (freeze-dried) powder form, depending on application and customer requirements. Long shelf life: Typically 12-24 months when stored at -20°C for lyophilised forms, with stability maintained through proper storage and packaging. Beyond its biological role, SOD has applications in nutraceuticals and dietary supplements. It could be used to enhance the body's natural defence mechanisms, particularly in combating oxidative stress that contributes to aging and chronic conditions. SOD supplements have potential to reduce inflammation, improve immune function, and support joint health. Some studies suggest that SOD may help mitigate symptoms of conditions like arthritis, asthma, and exercise-induced muscle damage.  In addition to health supplements, SOD is also utilised in the cosmetic industry due to its skin-protective properties. It helps reduce the impact of environmental factors, such as UV radiation and pollution, which accelerate skin aging. There are also potential pharmaceutical applications for reducing oxidative stress. The global market for superoxide dismutase (SOD) is experiencing significant growth, driven by increasing consumer demand for natural antioxidants, health supplements, sports nutrition, and anti-aging solutions. Superoxide dismutase market size was valued at USD 100 Billion in 2023 and is expected to reach USD 145.48 Billion by the end of 2030 with a CAGR of 5.6% (Verified Market Reports, 2024). Consumers are also leaning towards eco-friendly, naturally sourced, and sustainably produced products. SOD, produced via fermentation, aligns with this demand, offering a clean, green alternative to synthetic antioxidants, positioning it favourably in the market. Its unique properties as a potent antioxidant, coupled with advancements in production and delivery methods, position it as a high-value ingredient in the expanding nutraceutical, cosmetic, and pharmaceutical markets. Sustained action: Unlike non-enzymatic antioxidants like vitamin C or E, which are consumed in the process of neutralising free radicals, SOD continues to work through a catalytic cycle. This offers long-lasting protection against oxidative damage at lower dosages. Targeted oxidative stress protection: SOD directly neutralises superoxide radicals, one of the reactive oxygen species (ROS) that contribute to chronic inflammation, aging, and various diseases. Traditional antioxidants are less selective and less effective at targeting this specific radical. Versatile applications: SOD can be used in diverse formulations, from dietary supplements to topical skincare products which broaden its application in health, wellness, and cosmetics industries. Personal Care, Cosmetics & Hair, Nutrition & Health Supplements, Life Sciences, Industrial Biotech Methods & Processes, Sustainability, Sustainable Living

Liver Fluke Infection (Opisthorchis viverrine) caused by the ingestion of raw or uncooked fish containing parasitic worms is a significant health problem in several countries, especially Southeast Asia. This infection while not deadly, can cause acute gastro-hepatic inflammation and long-term infection leading to carcinogenesis of an aggressive bile duct cancer (Cholangiocarcinoma-CCA) if left undiagnosed and untreated. The lifespan of the human liver fluke ranges from 9 to 13.5 years. Hence, early diagnosis of O. viverrini infection is valuable in preventing the infection from worsening and causing complications. Current diagnostic method uses stool examination (restricted by low parasite egg numbers in the specimen), imaging tests of liver and blood tests for antibodies. Cysteine protease is a group of protease enzymes characterized in numerous infectious pathogens. This technology has discovered a single-chain variable fragment (scFv) antibody target against cathepsin F of O. viverrini (OvCatF) by using phage display technologies. Cathepsin F is an enzyme with a half-life that is highly released during the infection, detecting this protein could reflect the current infection. This novel scFv antibody holds great potential in the field of parasitology and infectious diseases, and the characterization of their immunological properties could pave the way for the development of an effective rapid diagnostic kit in the future. The technology owner is seeking for medical device companies to develop this potential target as a practical diagnostic procedure for O. viverrini infection in humans in the future. This invention is a mouse single-chain variable fragment (scFv) antibody that specifically recognizes the epitope on the cathepsin F protein of the human liver fluke Opisthorchis viverrini (OvCatF) on amino acid residues 11 to 30. This scFv antibody contains variable fragments (Fv) of both heavy chain (VH) and light chain (VL), which are connected by a disulfide bond to form a single chain. This scFv antibody is selected by biopanning from the murine naïve single-chain variable fragments (scFv) library and produced by recombinant protein technologies. The ultimate objective of this invention is to develop an effective diagnostic tool for opisthorchiasis and cholangiocarcinoma in the future. Antibody for development and diagnosis of Opisthorchis viverrini infection and cholangiocarcinoma (bile duct cancer). Therapeutic antibody for Opisthorchis viverrini infection. The UVP of this developed scFv antibody is such that it recognizes specific epitopes that have never been used, conserves less than the other parasites, and make low cross-reactivities. The evaluation of specific recognition of the particular epitopes and detection limits by both computational and laboratory performances demonstrated that the selected recombinant scFv antibodies against OvCatF could bind specifically to rOvCatF, and the lowest detection concentration in the study was only 100ng. This target antibody candiate has the potential to be commercialised for early rapid diagnosis of parasitic infectious disease through the development of a rapid test kit.    Single-chain variable fragment (scFv) antibody, Opisthorchis viverrini, Cathepsin F, Liver Fluke Infection Healthcare, Diagnostics, Medical Devices, Pharmaceuticals & Therapeutics

The rise in plastic pollution globally is driving a critical need for sustainable alternatives to single-use plastic in packaging. Traditional plastic-based packaging materials contribute significantly to environmental degradation, as they are non-biodegradable and create long-lasting waste. This technology offers a sustainable and eco-friendly solution through a fully biodegradable coating for paper packaging. The coating enhances the barrier properties of paper, enabling it to resist water, grease, and oxygen, making it an ideal replacement for single-use plastic in applications such as packaging and food containers. Not only does the coating maintain recyclability and biodegradability, but it is also compatible with existing manufacturing equipment and can be applied either before or after printing, minimising disruption to current production processes. The technology owner is interested to work on joint R&D opportunities with packaging companies and businesses focused on sustainable solutions for consumer goods. This technology is a proprietary coating formulation that can be applied to paper and fully biodegradable. Some features of the coating include: Enhances paper barrier properties against moisture, grease, and oxygen Food-grade (FDA approved) Fully recyclable and biodegrades in 180 days Scalable and compatible with existing manufacturing processes such as silk screen, rotogravure and flexography Can be applied before or after printing Thermally cured at 120 °C for 30 seconds Improves mechanical properties of pure paper This technology is suitable for a wide range of industries, including food and beverage packaging (such as cups, containers, and wrappers), cosmetics (biodegradable packaging for beauty products), and general consumer goods packaging. It serves as a sustainable alternative to traditional plastic-based barriers, providing an eco-friendly solution that meets the increasing consumer demand for environmentally conscious products. Environmentally sustainable as it provides the same protective qualities as synthetic plastic, with the added benefits of full biodegradability and recyclability Cost-effective coating solution Scalable solutions as it is compatible with existing production processes for application sustainable packaging, biodegradable coating, coating, greaseproof, oilproof, waterproof, circular economy, food packaging, paper packaging, eco-friendly, recycling, recylability, plastic alternative Chemicals, Coatings & Paints, Inorganic, Foods, Packaging & Storage, Sustainability, Circular Economy

The rapid growth of the Internet of Things (IoT), 5G, and Artificial Intelligence (AI) is driving the miniaturization, integration, and diversification of electronic devices. Till date the fabrication of electronics parts is largely based on traditional methods which does not lead themselves well to the construction of 3D electronic structures. Printed electronics are largely based on non-functional printing technologies which are optimised for 2D printing. Despite the potential, current 3D printing technologies face challenges in material compatibility, resolution, and complexity, making it difficult to create intricate, multi-material electronic devices. A novel approach using selective metal deposition (electroless deposition) combined with projection micro-stereolithography (PµSL) 3D printing offers a solution to address many of the challenges faced. This technology allows the creation of complex metal-plastic hybrid microstructures, potentially extending to other material combinations such as ceramic-metal, glass-metal, and semiconductor-metal hybrids, advancing the capabilities of 3D printed electronics. Besides, the 3D fabrication technique, the other core aspect of the solution included the know-how to formulate the special precursor materials that will allow metallic portions to be printed in-situ. These will combine to form hybrid structures that are functional thereby making it possible to create functional 3D parts. The technology owner is seeking partners with complex applications that involved functional 3D parts to co-create and develop the new applications with them using this technology.     The technology platform features an innovative approach for creating micro-hybrid devices through multiphase and multi-material integration. The core of the additive manufacturing technique involved the combination of UV light-based projection micro-stereolithography (PµSL) combined with electroless deposition method. It employs active precursor materials, specifically an active polymer that induces selective metal deposition, acting as a bridge between plastic and metal. Key technical features include: Multiphase and Multi-Material Integration: Enables the fabrication of devices with diverse material properties (e.g., conductive, insulating, and structural) in a single manufacturing process. High-Resolution Accuracy: Achieves micron-level precision, essential for producing complex, next-generation electronic components. Multifunctional Material Compatibility: Supports a wide range of materials, including conductive metals, ceramics, and advanced polymers, allowing for the creation of multifunctional devices. Enhanced Design Flexibility: Overcomes traditional manufacturing limitations, enabling the creation of complex geometries and hybrid material designs tailored for specific electronic functions. Scalability and Customization: Facilitates rapid prototyping, scalable production, and customized solutions, particularly for niche applications. Largest work piece: 100mm x 100mm x 100mm Smallest resolution: 2.5um Its potential applications include but are not limited to: Electronics Manufacturing 3D Electronics Intelligent Manufacturing for Robotics Medical Devices Semiconductor Manufacturing Automotive Energy Storage & Management Internet of Things (IoT) Devices Fast Fashion Jewellery & Accessories The technology can revolutionize the production of electronic devices by seamlessly integrating metals and plastics into complex, high-resolution microstructures. This process combines multi-material 3D printing with in-situ metal deposition to provide unrivalled design flexibility, precision and efficiency. By overcoming traditional manufacturing constraints, this technology delivers highly customizable, functional components that can set a new benchmark in the production of advanced electronics. Multi-material 3D Printing, Selective Metallization, Microstructures, Hybrids, Electronic Devices, Sensors, 3D Printed Jewellery Materials, Semiconductors, Plastics & Elastomers, Metals & Alloys, Manufacturing, Additive Manufacturing

The rise of digitalization of infrastructures via digital twins and increased industrial automation, there is an increased need for better prepared for cyber and physical attacks. The digitalization trends also underscore the increased threat of cyber or physical (“cyber-physical”) attacks that can now easily crimple critical infrastructures if unprepared. The technology owner leverages on the use of a digital twin and mock-up infrastructure to develop a technology solution that is able to mimic and simulate the behaviors of a physical infrastructure under cyber-physical attack. The realistic simulation and have been developed with a focus on large-scale cyber exercises such as Locked Shields (a cyber defense exercise by NATO CCDCOE) in mind. The digital platform enables users to understand and evaluate potential weakness of existing infrastructure via simulated cyber-physical attacks on operational technology (OT) to improve operation resilience. The digital platform is not dependent on the mock-up infrastructure and can be customized for specific simulations. The technology owner has successfully emulated a cyber twin of a Secure Water Treatment System (SWaT) with a physical testbed system for a testbed to launch and study cyber-physical attacks in a realistic water treatment plant. The technology owner is seeking collaboration partners who wish to accelerate understanding and build resilience from potential cyber-physical attack via simulations of critical infrastructures. The technology solution of Secure Water Treatment System (SWaT), comprising of the mock-up IT/OT infrastructure and digital twin, includes the following functionalities: Emulation of IT and OT network for a realistic 6-stage water treatment plant with the following stages: Raw water inlet Chemical dosing Ultrafiltration UV dichlorination Reverse Osmosis Backwash Customizable learning management platform for specific cyber-physical attack simulations Launch attacks for both OT and IT attacks with integrated IT/OT anomaly detector Conduct simulated and live-firing exercises using a configurable classroom orchestrator software within a physical, remote, or hybrid setting (with remote monitoring of participants) Ability to enhance learning using AR/VR emerging technology This technology solution of simulating cyber-physical attacks can be used for enhancing cyber resilience in critical infrastructure such as: Energy and Utilities: Power plants, electrical grids, water treatment facilities, renewable energy systems. Oil and Gas: Drilling operations, refining processes, pipeline monitoring, distribution networks. Transportation and Logistics: Automated control systems for railways, ports, warehouses, and supply chain management. Chemical Processing: Reaction monitoring, safety systems, quality control in chemical production. Manufacturing: Production lines, assembly processes, quality control systems. The technology solution provides the capability to accelerate understanding of cyber-physical attacks by supporting live-firing cyber simulations at the scale of Locked Shields (from NATO CCDCOE). The solution platform enables customisable digital twin of infrastructures with a configurable management software to facilitate multi-modal learning. Due to the integrated IT and OT anomaly detector, specific IT or OT attack launcher can be provide simulate realistic scenarios to improve operational resilience. Infocomm, Computer Simulation & Modeling, Educational Technology

The trend for embracing industrial digitalisation and automation is increasing due to enhancement in productivity and operational efficiency it brings. However, as industries increasingly rely on more interconnected systems, the potential risks associated with cyber-attacks and system anomalies have grown significantly. With no method to monitor, verify and neutralise these digital attacks, this makes them more vulnerable which can potentially cripple their critical infrastructures. The technology owner has developed a technology solution that leverages on advanced AI-driven technology to provide a robust defence mechanism, ensuring seamless and secure interactions between Information Technology (IT) and Operational Technology (OT) layers. Through the use of their proprietary AI algorithm, it is able to detect and neutralise anomalous network packets with the ability to incrementally learn in real-time. This not only results in preventing potential damage to critical industrial systems but also ensures continuity in production processes, thereby avoiding costly downtime and maintaining productivity. This technology solution helps businesses meet stringent cybersecurity compliance requirements, providing long-term cost-saving and peace of mind. The technology owner is currently undergoing pilot tests for critical water infrastructures, locally and overseas, by integrating this technology solution to existing industrial IT-OT control system. The technology owner is seeking industrial partners who are either open to explore integration into their critical infrastructure enhance their IT-OT cybersecurity or open to explore licensing opportunities. The technology solution to detect and neutralise anomalous network packets have the following capabilities: Real-Time Network Packet Decoding: Decodes network packets as they traverse the IT-OT layers, including PLCs, workstations, SCADA systems, and HMIs, ensuring that only legitimate data reaches its destination. AI-Driven Anomaly Detection: Utilizes advanced artificial intelligence to continuously monitor and analyze network packets flowing through IT-OT interaction layers, identifying any anomalies in real-time. Threat Detection and Intention Extraction: Detects potential cyber threats and extracts the attacker's intent from the anomalous packets, providing critical insights into the nature of the attack. Automated Threat Response: Automatically reports detected threats to plant management and discards malicious packets, preventing them from causing operational disruptions or pushing the plant into an anomalous state. Seamless Integration: Designed for easy integration into existing IT-OT infrastructures, the solution ensures minimal disruption during deployment and compatibility with a wide range of industrial systems. High Reliability and Precision: Offers high accuracy in anomaly detection with minimal false positives, ensuring that the critical infrastructure operates smoothly without unnecessary interruptions. Scalable Architecture: The solution can be scaled to fit different industrial environments, from small facilities to large, complex operations, ensuring robust security across various scales of deployment. The technology solution’s AI-driven anomaly detection and real-time monitoring capabilities make it an essential solution for safeguarding the interaction layers between IT and OT systems. Its ability to detect and neutralize threats before they impact industrial operations ensures the continued security and efficiency of critical infrastructure. This technology is particularly valuable in environments where seamless IT-OT integration and protection against cyber threats are crucial. The applications of the IT-OT Bridge include, but are not limited to: Energy and Utilities: Power plants, electrical grids, water treatment facilities, renewable energy systems. Oil and Gas: Drilling operations, refining processes, pipeline monitoring, distribution networks. Transportation and Logistics: Automated control systems for railways, ports, warehouses, and supply chain management. Chemical Processing: Reaction monitoring, safety systems, quality control in chemical production. Manufacturing: Production lines, assembly processes, quality control systems. The technology solution’s AI-driven ability to proactively detect and neutralise anomalous network packets before they can cause harm in real-time helps enhance the cybersecurity of IT-OT communication within any critical infrastructures. The proprietary AI algorithm enables incremental learning to further improve its high accuracy and precision with minimal false positives. With its seamless integration and scalable architecture, the deployment time required is reduced and can be scaled to fit various industrial environment, ensuring a reliable protection against potential cyber threat and ensuring the continuity and safety of any essential industrial operations. Infocomm, Security & Privacy, Networks & Communications, Artificial Intelligence

The use of traditional industrial adhesives faces persistent challenges, including VOC emissions, material waste, process bottlenecks, high energy consumption, and slow product iteration. These issues are leading to heightened regulatory scrutiny from environmental agencies and increasing demands for energy conservation and emission reduction. Furthermore, traditional adhesives manufactures do not meet the automotive and electronics industries' need for rapid product iterations. This microcapsule-based encapsulation technology (µCaps) addresses these challenges by enabling intelligent encapsulation and precise controlled release of adhesive components while minimizing environmental impact. Built on pioneering "Accurate Architecting Technology at the Micro- and Nano Interface" and a high-throughput µCaps screening and synthesis platform, this technology facilitates controlled, on-demand release and customizable core material functions in adhesives. It provides significant customization and operational flexibility while producing adhesives with lower VOC content, resulting in improved eco-friendliness, enhanced adhesion, and energy-saving properties. With precise control over the micro- and nanostructures of adhesive components, this technology is ideal for high-value applications in the automotive, electronics, and aerospace sectors. The technology owner positions itself as an innovative solution provider in the industrial adhesives sector, offering a range of µCaps to customers. They seek collaboration through joint R&D projects with adhesive manufacturers and companies in industries such as automotive, electronics, and aerospace. The focus is on those looking to penetrate the high-value-added industrial adhesives market, co-developing innovative products and applications that fully leverage this technology's potential. Based on the pioneering “Precision Architecture Technology for Micron and Nano Interfaces” and the high-throughput µCaps screening and synthesis platform, a fully proprietary and powerful platform technology has been constructed for specialty chemicals that can replace imported products and expand new application scenarios. Some features of µCaps include: Wide Range of Particle Sizes: From nanometers to millimeters Diverse Shell Materials: Organic, inorganic, metal/alloy, graphene, and composites Precise Control of Micro-Nano Structures: Including thickness, number of layers, surface roughness, density, and core materials Rapid and Agile Iteration Capability: Scaling from 1 formulation per day to 10n10^n10n formulations per day Superior µCaps Performance: Highly water- and solvent-resistant, high-temperature-resistant, and optimized for maximum strength and dynamic energy absorption Customizable: Allows for controlled release of components on demand Low VOC Content Potential applications of the µCaps technology include (but not limited to): Adhesives: Including structural, anaerobic sealants, and conductive/nonconductive adhesives Building materials: For thermal management and anti-fouling Cosmetics and food: As essence/perfume/cream/food additives carriers and anti-staling agents carriers or anti-staling agents Agriculture: For controlled release pesticides and fertilizers Biomedicine: Targeted drug delivery and enzyme encapsulation Other applications: Self-healing materials and personalized care products This technology stands out due to its high performance-to-price ratio, eco-friendly design (low VOC and waterborne), and energy-saving capabilities. It is customisable and adhesives produced offer superior performance, particularly in high-value industrial applications. adhesives, microcapsules, encapsulation, controlled delivery, low voc, eco-friendly, materials Materials, Composites, Chemicals, Inorganic, Manufacturing, Chemical Processes, Organic

This technology integrates artificial intelligence (AI) and robotics to create an autonomous experimentation system, aimed at significantly accelerating the discovery and development of energy materials. Traditionally, research and development (R&D) cycles in materials science are slow and resource-intensive, often taking years or even decades to produce meaningful results. However, this technology can reduce these timelines to under one month by leveraging advanced AI algorithms and robotic automation to optimize experimental processes in real-time. The system is designed to continuously refine experimental parameters based on data insights, enabling rapid prototyping and validation of new materials. This makes it a powerful tool for industries seeking to innovate within the renewable energy sector, as it allows for faster material discoveries and shorter times to market. The system’s precision, speed, and ability to handle high-throughput experimentation offer substantial benefits for energy-related applications, including the development of battery, fuel cell, and solar cell materials to name a few. The technology owner is seeking R&D projects, out-licensing and test-bedding opportunities with interested parties to develop new materials for energy, pharmaceutical industry and automotive applications.  This technology combines AI-driven models with robotics to create a fully autonomous platform capable of high-throughput experimentation for new material discovery. Key features of the system include: AI-Driven Experiment Optimization: The system employs AI not only for designing new materials and predictive modelling but also for automatic analysis and real-time interpretation of experimental data, continuously improving its processes. Robotic Automation: The system ensures precision in material synthesis and characterization through robotic automation, allowing for reproducibility and scalability. Closed-Loop Feedback: Each experiment's data is fed back into the AI system to guide future experimental efforts, enhancing both the speed and accuracy of material discovery The technology outperforms traditional R&D timelines, serving as a shortcut in the innovation cycle, going from a problem statement to productisation in a more rapid manner. This autonomous experimentation system is highly suited for industries that require rapid and efficient material development, such as: Energy Storage and Conversion: High-performance batteries, solar cells, and fuel cells Aerospace and Automotive: Lightweight materials, advanced polymers, and coatings Electronics: Semiconductor materials and other components requiring fast development cycles Accelerates R&D lead times through a combination of AI and robotics Enables automatic analysis and interpretation of experimental data, shortening the linear R&D processes High speed, accuracy, and cost-effectiveness in the discovery and development of advanced materials artificial intelligence, robotics, autonomous experimentation, research and development, rapid prototyping, materials, energy, battery, solar cell, fuel cell Materials, Semiconductors, Infocomm, Artificial Intelligence, Energy, Fuel Cells, Robotics & Automation, Chemicals, Organic

Cellular Senescence (ageing) is attributed by several phenomenon including the proliferation of inflammatory cytokines, proteases, inhibitory molecules, metabolites and tissue dysfunction. When a senescent cell has lost its cellular function, it is commonly termed as “Zombie cells”, incapable of being removed, at the same time afflicting cellular damage to neighboring cells. In the quest for longevity solutions, geroscience research has made progress in the development of druggable therapeutic targets and non-drug alternatives. Senolytics work by eliminating senescent cells to promote tissue regeneration, while senomorphics aim to suppress or neutralize senescence-associated secretory components and inflammation without killing the cells. This reduces the harmful effects on neighboring cells. This technology has identified plant-derived active ingredients with both senolytic and senomorphic properties, coupled with liponiosome-based encapsulation techniques for enhanced delivery and stability. These ingredients have been validated for safety and efficacy in human skin models and clinical trials and have been formulated for topical skincare serums. For nutraceuticals, separate senolytic and geroprotective products have been developed. These have been tested in cells, skin tissues, and C. elegans (for lifespan extension), and are currently undergoing clinical trials to assess long-term safety and anti-aging benefits in middle-aged volunteers.  The technology owner is looking to collaborate with: Cosmetic, nutraceutical companies seeking to incorporate scientifically proven anti-aging ingredients or co-develop new products. Research institutes and universities interested in collaborating on research related to aging biology and product development. This anti-aging technology integrates scientifically and clinically validated active ingredients into cosmeceutical and nutraceutical products. Key innovations include plant-derived active compounds that target senescent cells and key aging hallmarks such as inflammation and mitochondrial dysfunction. In cosmeceuticals, liponiosome-based encapsulation techniques are employed to enhance the stability and delivery of these ingredients, ensuring deep skin penetration for optimal anti-aging effects.   In addition, advanced efficacy and safety testing services are available, utilizing human skin models, including 3D reconstructed and ex vivo human skin. These models evaluate the performance of active ingredients, cosmetics, and supplements for anti-aging benefits, skin rejuvenation, and safety, ensuring that product claims are substantiated and meet regulatory standards. This anti-aging technology applies to cosmetics, nutraceuticals, and wellness industries, offering longevity-focused solutions that target aging hallmarks and enhance beauty, health, and longevity.This technology and its active ingredients can be customized for companies in the anti-aging nutraceutical and cosmeceutical sectors, targeting Gen X and Y consumers (aged 35-65) who seek research-backed beauty and health solutions. The global anti-aging market is projected to reach over $88 billion by 2026, driven by rising consumer demand for scientifically backed, effective solutions that address the root causes of aging. This technology is highly attractive due to its unique approach, which targets cellular aging hallmarks such as senescent zombie cells, offering more profound results than traditional products. With increasing awareness of longevity and wellness, active ingredients, cosmeceuticals and nutraceuticals focused on extending healthspan are in high demand. This technology provides a competitive edge by offering scientifically and clinically validated products that cater to the growing market for premium, research- backed anti-aging treatments, appealing to both B2C consumers and B2B partners, including cosmetic manufacturers, nutraceutical companies, and wellness providers. This technology delivers science-backed, drug-level efficacy through its Senolytic and Senomorphic active ingredients, targeting cellular aging and key hallmarks of aging with award-winning innovations from Paris, Switzerland, and Thailand. Developed by researchers specialized in aging biology, these ingredients and products have been rigorously validated in cells, human skin, and clinical trials, ensuring proven safety and superior performance. On Senolytic Cosmeceutical Actives: Eliminates aged senescent cells by 46%, comparable to the efficacy of the experimental anti-cancer drug Navitoclax. Restores mitochondrial function by 60%, revitalizing cellular energy. Increases the elimination of senescent "zombie" cells by 255%. Stimulates hyaluronic acid production by 484%, significantly enhancing skin hydration and plumpness. Boosts collagen production by 94%, improving skin elasticity and firmness. Reduces inflammation by 40-55%. Inhibits melanin production by 38%. Clinical Results: Non-irritant and hypoallergenic. On Senomorphic Cosmeceutical Actives: Reduces senescent cells by 75%. Decreases aging-related inflammation by 32-47%. Stimulates hyaluronic acid production by 173%. Boosts collagen production by 103%. Reduces melanin production by 59%. Clinical Results: Non-irritant. On Senolytic Cosmeceuticals: Promotes the removal of senescent cells by 158% in aged human skin (ex vivo) Boosts collagen synthesis by 79% in aged human skin (ex vivo) Suppresses aging-related inflammation by 50-85% in aged human skin (ex vivo). Reduces melanin production by 29% in 3D pigmented skin models Clinical Trial Results (56 Days): Reduced wrinkles by 33.1%. Improved skin hydration by 36.1%. Increased skin elasticity by 20.5%. Non-irritant and hypoallergenic. On Senomorphic Cosmeceuticals: Alleviating Damage from UV, Blue Light, and PM 2.5 (ex vivo human skin): Inflammation Reduction: Decreases inflammation by 58-60% (IL-6 and MMP-1 markers). Free Radical Reduction: Lowers ROS production by 20%. Hyaluronic Acid Synthesis: Boosts hyaluronic acid production by 36%. Clinical Trial Results (56 Days): Reduced wrinkles by 23.6%. Improved skin hydration by 40.5%. Increased skin elasticity by 16.1%. Enhanced skin brightness by 6.2%. Non-irritant. On Senolytic Supplement: Destroys 60% of zombie cells (tested in senescent human fibroblasts). Increases zombie cell clearance by 75x, comparable to Navitoclax and Dasatinib + Quercetin (tested in aged ex vivo human skin). Restores mitochondrial energy by 102% (tested in free radical-damaged fibroblasts). Decreases free radical production by 64% and reduces inflammation by 27-34% (tested in aged ex vivo human skin). Reduces melanin production by 22% (tested in melanoma cells). Clinical Results: Brightened and hydrated skin after 10 days of use. On Geroprotective Supplement: Reduces senescent cells by 75% (tested in senescent human fibroblasts). Decreases aging-related inflammation by 32-47% (tested in aged ex vivo human skin). Stimulates hyaluronic acid production by 173% (tested in aged ex vivo human skin). Boosts collagen production by 103% (tested in aged ex vivo human skin). Reduces melanin production by 59% (tested in 3D pigmented skin models). Clinical Trials: Undergoing clinical trials for long-term safety and anti-aging benefits in middle-aged volunteers. The technology owner has commercialized finished products in the range of cosmetics and geroprotector supplements using a combination of senolytics and senomorphics formulations, tested for its safety and efficacy. Longevity, Anti-Ageing, Senolytic, Senomorphics, Geroprotector, Cosmeceuticals, Nutraceuticals, Ex Vivo Human Skin, 3D Human Skin Model, Rejuvenation, Active Ingredients