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Biomarkers are biomolecules and/or physical characteristics found in the body that give a clear picture of a person’s health and fitness. Currently, the golden standard of biomarker testing is through blood tests. However, this method is invasive as it involves drawing blood with a needle. Additionally, blood tests are neither real-time nor continuous which means there is significant delay between testing and receiving results. Such problems can be solved through this invention as this method involves sensing biomarkers within sweat through a skin patch, eschewing the need for needles. Furthermore, the biomarker data can be instantly transmitted to a smartphone application which allows users to continuously monitor their data in a convenient manner.  This technology would be relevant in numerous industries such as sports fitness, beauty, and medical diagnostics; thus, attracting sizable demand for it where there is an unmet need for convenient, accurate and real time detection of accurate biomarkers.

Amidst the imposition of compulsory climate reporting by regulatory bodies in some nations including Singapore, a powerful carbon accounting software solution has been devised. This aims to aid and fortify companies in their readiness to adhere to this necessity and embark on their sustainability journey. The software suite consists of the following solutions: GHG Emissions Management: Efficiently manage and reduce your organisation's greenhouse gas (GHG) emissions. ESG Reporting: Streamline and simplify your Environmental, Social, and Governance (ESG) reporting process. Environmental Compliance: Propel your organisation towards comprehensive ISO 14001 environmental stewardship. 24/7 Electricity Emissions Traceability: Navigate your decarbonisation journey with real-time, precise and transparent electricity emissions tracking.

In 2022, about 83 million patients suffer from insulin-dependent diabetes worldwide. From 2021 to 2045, this number is projected to increase by 46% globally. Despite the availability of approved insulin therapy as the standard of care, up to a quarter of these patients still suffer from poor blood glucose control, which can lead to a fatal drop in blood glucose levels. The team has developed a cell-encapsulating macro-device as an implant to reduce the risk of fatal drop in blood sugar of insulin-dependent diabetic patients. This patent-pending, injection-free cellular implant can effectively manage insulin-dependent diabetes by enabling enhanced survival of therapeutic insulin-secreting cells. After a simple under-skin insertion of the macro-device, the cells in this implant can sense the blood glucose level of a diabetic patient and secrete insulin to continuously provide injection-free, precise glucose control. The device also protects the insulin secreting therapeutic cells by encapsulating them in a hydrogel to shield them from immune attacks and alleviate the patient from the need for immunosuppression. This technology could offer a safer alternative treatment for these insulin-dependent patients who experience poor blood glucose control with conventional insulin therapy.

Histopathology is a cornerstone of modern medicine, providing crucial information that enables doctors to formulate optimal treatment strategies before, during, and after surgeries. However, current methods for obtaining histological images grapple with a compromise between speed and accuracy and suffer from organ-dependent inconsistencies. Addressing these challenges, our technology was developed as a versatile solution to cater to a wide array of clinical scenarios. It sets a new benchmark for medical standards with its rapid, precise, and label-free on-the-spot imaging capability. Computation High-throughput Autofluorescence Microscopy by Pattern Illumination is a one-of-a-kind patented solution n that can detect and provide instant information about cancer status before, during, and after surgeries. This technology lets surgeons place fresh tissue samples taken directly from the patient into the microscope and receive high-resolution and virtually stained histological images in just three minutes. The primary adopters of this technology are expected to be healthcare organizations, hospitals, and research institutions, or any entity involved in histopathology, cancer diagnosis, and surgery. This technology fills a crucial void in the market by providing swift, high-resolution, label-free imaging of thick tissue samples, an achievement previously unattainable. Consequently, this technology not only accelerates the diagnostic process but also enhances its precision, revolutionizing the field of histopathology

Patients who have stroke, brain injuries, cerebral palsy, arthritis or suffer from other neurological disorders often experience motor impairments; patients with delayed or lack of rehabilitation suffer from more severe physical sequelae, such as, spasticity and muscle atrophy, which decreases their level of independence It has been reported by World Health Organisation, that the need for rehabilitation continues to grow worldwide, especially in low- and middle income countries. The demand for rehabilitation services already exceeds availability, leaving a large unmet need. Longer life expectancies and increasing survival rates for those with severe disability, coupled with the rising prevalence of chronic diseases means that globally there will be an increase in the health burden associated with limitations in functioning. For both the patients and therapists, there is a need for efficient models of rehabilitation care are needed. This invention is of a robotic manipulator that can assist or be programmed to move or mobilize patients’ limbs or joints repetitively during rehabilitation or to perform daily tasks, for e.g., of gripping a cup, bowl or utensil, in a safe, reliable and effective manner. The device can be used in a clinical and/or at-home setting.

Immune cell activation and expansion for cell therapy is a strictly regulated process. It demands costly and labour-intensive optimization of cell culture conditions. Major limitations of these processes are cell quality and results consistency. Large amounts of expenses were spent on culture conditions, cell characterizations and quality control (QC) with differing culture protocols and recipes in growing CAR-T cells. This technology has established a standardized platform through its feeder-cell mimicking feature that could screen culture conditions for diverse cell types and patient source more rapidly at lower costs. Both feeder-cell based system and feeder-free system poses respective challenges of contamination or insufficient growth signals. To address this gap, a modular, all-signals-in-one microbead-based platform has been developed for the next-generation cell therapy R&D and translation. In this delivery platform design, the modular feature allows rapid ‘plug-and-use’ of multiple surface and soluble signals to grow T-cells ex vivo without the need for extensive setup and integration of culture protocols. This platform aims to provide a seamless and straightforward cell culture experience for the industrial and academic research users to discover new types and applications of immune cell therapy. Additionally, the all-signals-in-one synthetic platform mimics the natural antigen presenting cells to activate and expand T-cells on dish, allowing cell manufacturers to ‘mix-and-grow’ immune cells with reduced effort or technical expertise. This aims to improve the cost-effectiveness and scalability of cell therapy manufacturing. The technology provider is seeking collaborations with cell therapy CDMOs/CMOs in licensing and various R&D developments.

This technology portfolio covers wearable sensing and haptics for Virtual Reality (VR). The wearable sensors can provide gesture-based control in VR without the need for cameras, providing interactive control for VR for lower end headset. The sensor use electronic textiles and a patented sensing scheme that requires no additional electronics except a microcontroller. They present ultralow latency (<1ms), can distinguish between wearer and non-wearer and have exceptional noise rejection. The haptics technology allows for simulation of resistance and micro sensations on the fingers and palm. This is crucial for applications like surgical training, as surgeons routinely rely on their sense of touch in real world scenarios. The jamming technology uses textile-based actuators and pneumatics, making it the lightest wearable technology for haptics.

Systemic drug administration has conventionally been prescribed to alleviate persistent local inflammation which is prevalent in chronic diseases. However, this approach is associated with drug-induced toxicity, particularly when the dosage exceeds what is necessitated from the pathological conditions of the diseased tissues. This technology developed is a novel drug delivery technology that is activated to enable the release of appropriate drug payload according to the patient’s condition on the level of disease severity. The drug delivery system is a modular hybrid hydrogel carrier encapsulating the required anti-inflammatory drug which is triggered to release upon exposure to elevated markers of inflammation such as increased protease activity which is commonly upregulated in inflammatory diseases.   The technology has been validated for its material, safety, and toxicity studies on ex vivo exudates of clinical samples, in vivo wound model, and arthritis diseased mouse model. The primary targeted indication is Rheumatoid arthritis based on its significant disease unmet need and market size. It aims to become a platform technology as an effective therapy against chronic inflammatory diseases such as inflammation bowel diseases, chronic wounds and topical application. The convenience of the technology offers significant societal benefits, particularly for ageing populations where the incidence of pain and inflammation arising from diseases becomes prevalent with age while potentially eliminating adverse side effects from traditional delivery of drug administration.  The technology owner is seeking for collaborations with clinicians, biopharma, biotech companies looking for novel drug delivery systems.

With the recent surge in the risk of pathogens and viruses, there has been a strong demand for hygiene-focused products globally. In public health, there is an increasing need to obtain more sterilised water and to create a hygienic environment with sterilised water. Ozone dissolved in water, commonly known as ozonated water, has been used to produce safe drinking water at water purification plants because of ozone's sanitising properties. However, conventional gas dissolution methods have limited their applications because it is difficult to incorporate both safe ozone production and ozone dissolution into water in the same small product. This technology is a modular sanitary device that is able to electro-produce ozonated water for sanitisation. This device can, on-demand, instantly generate ozonated water via electrolysis. The ability for on-demand generation circumvents the problem where ozonated water loses its sanitising properties over time. Furthermore, this modular device can be easily designed to have variable performance depending on the number of devices connected and the control of current and flow rate. Therefore, the device can be easily designed to be integrated into existing products (e.g., household water purifiers, etc.). Lastly, this compact device that can efficiently generate sterilising ozone water is expected to address dissolution problems in various systems such as public health, medical treatment, etc.