Sustainable Living: Health and Well-being

Norovirus is a highly contagious non-enveloped virus responsible for causing >90% of viral gastroenteritis, and >50% of all gastroenteritis outbreaks worldwide. According to the WHO, norovirus causes an estimated 685 million cases of infection and 200,000 deaths per year. Its resilience poses challenges for eradication through altering pH, heat exposure, or common disinfectants. Notably, alcohol-based hand sanitisers are not as effective against this virus, according to the US CDC. To address this, a biotech company has successfully developed a novel virus-binding protein technology derived from jack beans or sword beans. This patented lectin protein exhibits antiviral properties and has demonstrated the ability to neutralise not only norovirus, but also coronavirus and Hepatitis A virus. It has also demonstrated activity against Escherichia coli bacteria.  By utilising this innovative technology, viral outbreaks can be prevented. This versatile lectin protein can be incorporated as an active ingredient into various product formulations. The technology owner is especially interested to work with companies from health service sectors, and personal care product manufacturers.

A challenge faced by many chemical processing plants is the high process temperature and high energy consumption. For example, in the Traditional Chinese Medicine (TCM) production process, one of the commonly used approaches of concentrating the medicine is by evaporation. This process operates at 100°C and aims to remove 2/3 of the total amount of water from the feed solution. The main issues are: High operating temperature causing irreversible damage to the active ingredients. Taking up 75% of the overall energy consumed. 2-3 days to process one batch of the extracted liquid. Labour-intensive and hard to scale up. Furthermore, as the production is operated in batch mode, the boiler needs to be turned off and on (heating and cooling) frequently. To overcome these challenges, the membrane – pervaporation system has been developed. The operating principles have been tested at laboratory scale using actual TCM products. The operating temperature can be lowered so that the risk of damage to the active ingredients is reduced. It was computed that an energy saving of 39% can be achieved. The team that designed and developed the system is well-versed with membrane technology and is ready to transfer the know-how and knowledge. They are seeking partners to collaborate and further develop this proof-of-concept for commercial deployment, targeting applications where thermal damage to high value active ingredients are of concern.     

This technology is a patented synbiotics (combination of probiotics and prebiotics) cleaning solution that offers a safe and sustainable alternative to traditional cleaning products and disinfectants. When released onto the surface, the probiotics will digest and break down dirt, grime, and other unwanted substances while the prebiotics in the solution act as an additional source of nutrition for the probiotics. The resultant surface microbiome provides a continuous cleaning effect that is longer lasting than traditional cleaning chemicals and disinfectants. Often, the overuse of traditional chemicals and disinfectants results in antimicrobial resistance (AMR), allergenic reactions to the user, negative impact on the environment and short effective lifespan. With this synbiotics technology, users can overcome these limitations and achieve a long-term effective cleaning system and a natural microflora to the environment. When utilised in healthcare settings, the synbiotics cleaning solution demonstrated a higher reduction of pathogens (80% more), decreased AMR (up to 99.9%) and health-associated infections (52% lesser). The technology owner is interested in co-development projects and test-bedding opportunities with companies looking for a sustainable and long-lasting cleaning technology i.e., cleaning equipment and automation manufacturers/suppliers and cleaning service providers.

One-third of the food produced globally is lost or wasted. At the same time, millions of people are hungry and unable to afford a healthy diet. Having said that, food loss and waste could potentially impose food security and impact the world with nutrition, socioeconomic, and environmental issues.  This technology offer is a process technology that provides an efficient and environmentally friendly approach to utilise agri-food side stream and convert it to a valuable, high protein biomass. The technology develops precision approaches, i.e., the proper treatment methods for food sidestreams, specific separation means for target ingredients, suitable strains for protein production, and optimized operational conditions for the fermentation process. The process also utilises the inexpensive agri-food side stream as the novel feedstock for protein fermentation. The technology is available for R&D collaboration and test bedding, with partners that are interested in valorisation of food sidestreams to value-added edible protein. The technology owner is also keen to license and commercialize this technology.

Many active ingredients in formulated products often suffer from degradation triggered by light, heat, mechanical stress or volatile loss, as well as incompatibility issues with other ingredients or excipients. Encapsulation of actives could be a solution, however existing methods including nanoemulsion, liposomes, nanostructured lipids, spray drying involve undesirable steps that use organic solvents, surfactants, alcohols, non-biodegradable polymers and high shear processes. These undesirable steps render difficulties for economical scale-up.   The technology provider has developed a novel method for producing a biodegradable polymer that is based on green chemistry and easily scalable. Through their simple and novel nanoencapsulation process, the technology allows the encapsulation of most actives at submicron scale to form water-based formulation without the forementioned undesirable steps. This technology presents a low-cost, scalable co-block amphiphilic biodegradable polymer-based nanoencapsulation that is of superior performance and stability due to its polymeric chain entanglement and nano-sized effects.   The technology provider is seeking collaborations with partners, including  actives manufacturers and formulated products owners, who may have interests to adopt this encapsulation technology for hydrophobic actives in applications including insect repellents, pesticides, skincare, aromatherapy products, and pharmaceutical applications.  

Many existing smart city solutions only show the impact of urban development, but few show the impact that urbanisation imposes on daily activities and long-term outcomes such as population obesity and job availability/accessibility. In short, such solutions show the activities e.g. large crowds are visiting the neighbourhood park, that are happening in real-time (what), the location (where), and the time that they occur (when), but do not have the ability to include data that makes it possible to explain the reason for such activities (why). In order to bring about any intervention or identify missed opportunities, understanding the reason behind such activity is vital. This technology utilises data on city infrastructure systems to help users understand how and where the built environment creates a set of physical constraints that influence what planned and unplanned activities are possible, and in turn how this influences long term outcomes including health and climate change. This technology imports, translates and combines datasets into spatialised models which are used to generate analytics outputs. These outputs include a comprehensive explanation of the way streets, pedestrian networks, public transport and land use interact with each other. In this manner, socio-economic and/or demographic datasets can be linked, enabling people and places to be combined in a single analytical model.

Conventional diagnostic imaging of the skin involves the use of dermatoscopes. Dermatoscopes use skin surface microscopy to examine dermal and sub-dermal tissues to diagnose skin problems. However, these devices can be costly and provide a limited view of the immediate skin surface. This limitation meant that dermatoscopes have to be used in direct contact with the patient's skin. Because of this, they can only be used to image patients in the same physical location as the clinician conducting the examination. The overall result is that only a tiny portion of the global dermatology patient-base can be reached cost-effectively and efficiently. Telemedicine and telehealth network operations are rapidly developing ways to address patients broadly and at lower costs for them and their care providers. Yet, such tools neither deliver desmatoscope-like functionality nor improved it in way that it allows patients' skins to be examined and analysed during an online medical consultation with a general practitioner. In order to facilitate remote skin disease diagnosis, the use of software is required to acquire and share images in real-time and ideally, by the patients themselves. This software enables patients to take their medical sub-skin images with their mobile, tablet or laptop cameras, and securely share it with doctors. Crucially, dermatoscopy images can also be used with the technology to improve diagnostic accuracy. This technology is intended to position itself as a technology which when scaled-up, could allow for products that can enable optical biopsy and phototherapy. 

There are 30,000 occupational drivers in Singapore, out of which 13,500 are 45 years old and above. The risk of acquiring cardiovascular disease increases with age and is potentially exacerbated by low physical activity and high emotional stress levels, which are two typical characteristics of occupational drivers arising from their work environment. Low level of physical activity and high stress levels have been shown to have significant relationship with heart rate variability, one of the indicators of cardiovascular disease. This technology is developed to help drivers to monitor their stress level, provide them with instantaneous feedback and the necessary alerts for a timely intervention. This technology offer presents a cross-platform AI system that estimates the stress levels continuously in real time, and can be easily integrated with commercially available photoplethysmography (PPG) wearables, e.g., a PPG wristwatch. In addition, this technology can be adapted for the monitoring of workplace stress with the aim of improving overall mental well-being.

The Dilution Air Processing Unit (DAPU) is an ideal solution for small and medium businesses to prepare themselves for the Covid-19 new normal by employing an enhanced air ventilation technique. The DAPU system allows the creation of zones (e.g. sickbays, waiting rooms, etc.) within workplaces with no recirculation of air. This prevents cross-contamination of unclean air in between the zones. This solution is suitable for hotels and other premises to be used for quarantine purposes. The DAPU consists of the following key features: Provides 100% fresh air supply with no recirculation Reduces airborne particles exposure by greater than 60% Achieves 25% energy efficiency in providing 100% fresh air supply as compared to conventional systems Uses fully portable modular approach Can be easily retrofitted to any existing air-conditioning system resulting in lower implementation cost The DAPU can also be deployed in any area without an existing air-conditioning system making it highly versatile.